LineagePulse

This package is for version 3.9 of Bioconductor. This package has been removed from Bioconductor. For the last stable, up-to-date release version, see LineagePulse.

Differential expression analysis and model fitting for single-cell RNA-seq data


Bioconductor version: 3.9

LineagePulse is a differential expression and expression model fitting package tailored to single-cell RNA-seq data (scRNA-seq). LineagePulse accounts for batch effects, drop-out and variable sequencing depth. One can use LineagePulse to perform longitudinal differential expression analysis across pseudotime as a continuous coordinate or between discrete groups of cells (e.g. pre-defined clusters or experimental conditions). Expression model fits can be directly extracted from LineagePulse.

Author: David S Fischer [aut, cre], Fabian Theis [ctb], Nir Yosef [ctb]

Maintainer: David S Fischer <david.fischer at helmholtz-muenchen.de>

Citation (from within R, enter citation("LineagePulse")):

Installation

To install this package, start R (version "3.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("LineagePulse")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("LineagePulse")
LineagePulse HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews CellBasedAssays, CellBiology, DifferentialExpression, GeneExpression, ImmunoOncology, Sequencing, SingleCell, Software, StatisticalMethod, TimeCourse
Version 1.4.0
In Bioconductor since BioC 3.7 (R-3.5) (6 years)
License Artistic-2.0
Depends
Imports BiocParallel, circlize, compiler, ComplexHeatmap, ggplot2, gplots, grDevices, grid, knitr, Matrix, methods, RColorBrewer, SingleCellExperiment, splines, stats, SummarizedExperiment, utils
System Requirements
URL
Bug Reports https://github.com/YosefLab/LineagePulse/issues
See More
Suggests
Linking To
Enhances
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package LineagePulse_1.4.0.tar.gz
Windows Binary LineagePulse_1.4.0.zip (32- & 64-bit)
Mac OS X 10.11 (El Capitan) LineagePulse_1.4.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/LineagePulse
Source Repository (Developer Access) git clone [email protected]:packages/LineagePulse
Bioc Package Browser https://code.bioconductor.org/browse/LineagePulse/
Package Short Url https://bioconductor.org/packages/LineagePulse/
Package Downloads Report Download Stats
Old Source Packages for BioC 3.9 Source Archive